Systemic Inflammatory Response Syndrome Insepsis-3: A Retrospective Study

Despite considerable medical advances, sepsis is common and associated with high morbidity and mortality rates [1,2]. In 1991, the Task Force in the First International Consensus Conference used expert opinion to generate the then-current definitions of sepsis (First International Consensus Conference Definitions for Sepsis and Septic Shock [Sepsis-1]) based on the presence of systematic inflammatory response syndrome (SIRS) [3]. Because of high sensitivity and low specificity, Sepsis-1 was replaced by Sepsis-2 in 2001[4]. However, Sepsis-2 did not show superiority over Sepsis-1 in the diagnosis of sepsis [5]. In 2015, a study of SIRS in patients with severe sepsis completely disclosed the flaws of the SIRS criteria, prompting further revision of the sepsis definition [6]. In 2016, the Third International Consensus Conference established a new sepsis definition (Sepsis-3) [7]. In Sepsis-3, the Sequential (Sepsis-related) Organ Failure Assessment (SOFA) criteria, rather than the SIRS criteria, are used as the basis for the definitions of sepsis and septic shock (Figure 1).